Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
Recombinant Human SIRP gamma/CD172g Protein (Fc Tag)
£93.60 – £297.00 excluding VAT
| Size | 10µg, 50µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | Recombinant Human Signal-Regulatory Protein gamma is produced by our Mammalian expression system and the target gene encoding Glu29-Pro360 is expressed with a Fc tag at the C-terminus. |
| Sequence | Glu29-Pro360 |
| Fusion Tag | C-Fc |
| Accession | Q9P1W8 |
| Species | Human |
| Expressed Host | Human Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 63.9 kDa |
| AP Mol Mass | 80 kDa |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Research Areas | immunology |
| Reconstitution | Please refer to the printed manual for detailed information. |
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