Recombinant Human SULT2B1 Protein (aa 2-365, His Tag)

Sulfotransferase family cytosolic 2B member 1; also known as Sulfotransferase 2B1; ST2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1 and HSST2; is a cytoplasm protein which belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies; SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta; prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms; SULT2B1a and SULT2B1b; are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol; whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.