Syndecan-1 is a single-pass type I membrane protein that belongs to the syndecan proteoglycan family. The syndecans mediate cell binding; cell signaling; and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. Human SDC1 is synthesized as a 310 amino acid precursor that contains a 22 amino acid signal sequence; and a 288 amino acid mature chain. The Syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation; cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered Syndecan-1 expression has been detected in several different tumor types.
Recombinant Human Syndecan-1/SDC1 Protein (Fc Tag)
£103.20 – £375.00 excluding VAT
Size | 10µg, 50µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Recombinant Human Syndecan-1 is produced by our Mammalian expression system and the target gene encoding Gln18-Glu251(Leu136Gln) is expressed with a Fc tag at the C-terminus. |
Sequence | Gln18-Glu251(Leu136Gln) |
Fusion Tag | C-Fc |
Accession | P18827 |
Species | Human |
Expressed Host | Human Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 51 kDa |
AP Mol Mass | 80-90 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 . |
Research Areas | Signal Transduction, Neuroscience, Cancer, metabolism, Stem cells |
Reconstitution | Please refer to the printed manual for detailed information. |
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