Fagus Antibody Services

Recombinant Human TC­PTP/PTPN2 (C-6His)

£132.00£397.60 excluding VAT

Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also known as PTPT and TC-PTP, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation.TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E.coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.

Sequence

Thr2-Asn314

Fusion Tag

C-6His

Accession

P17706

Species

Human

Expressed Host

E.coli

Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Mol Mass

37.4 kDa

AP Mol Mass

35-40 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 300Mm NaCl, 1mM DTT, 10% Glycerol, pH 7.4.

Research Areas

Signal Transduction

Reconstitution

Not Applicable

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