Fagus Antibody Services

Recombinant Human TGFB1/TGF-beta 1 Protein (His Tag)

£142.40£523.00 excluding VAT

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Human TGFB1 is produced by our Mammalian expression system and the target gene encoding Leu30-Ser390(Cys33Ser) is expressed with a 8His tag at the N-terminus.

Sequence

Leu30-Ser390(Cys33Ser)

Fusion Tag

N-His

Accession

P01137

Species

Human

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

41.3&12.8 kDa

AP Mol Mass

38-55 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of 50mM Glycine, 50mM NaCl, pH4.0.

Research Areas

Signal Transduction, Cell biology, Cardiovascular, Cancer, metabolism, Stem cells

Reconstitution

Please refer to the printed manual for detailed information.

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