Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Recombinant Human TGFB1/TGF-beta 1 Protein (His Tag)
£142.40 – £523.00 excluding VAT
Size | 10µg, 50µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Recombinant Human TGFB1 is produced by our Mammalian expression system and the target gene encoding Leu30-Ser390(Cys33Ser) is expressed with a 8His tag at the N-terminus. |
Sequence | Leu30-Ser390(Cys33Ser) |
Fusion Tag | N-His |
Accession | P01137 |
Species | Human |
Expressed Host | Human Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 41.3&12.8 kDa |
AP Mol Mass | 38-55 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of 50mM Glycine, 50mM NaCl, pH4.0. |
Research Areas | Signal Transduction, Cell biology, Cardiovascular, Cancer, metabolism, Stem cells |
Reconstitution | Please refer to the printed manual for detailed information. |
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