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Recombinant Human TIGIT Protein (His & Avi Tag)

£273.60 – £924.00 excluding VAT

SKU FAS-033793-P Category Tag

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated; memory and regulatory T cells; and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation; while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2; which also interact with DNAM-1/CD226 and CD96/Tactile; TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular; TIGIT binding to CD155 can antagonize the effects of DNAM1.

Size

20µg, 100µg
Active Protein
Activity
Protein Construction

Biotinylated Recombinant Human TIGIT is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His; Avi tag at the C-terminus.
Sequence

Met22-Pro141
Fusion Tag

C-His-Avi
Accession

Q495A1
Species

Human
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

15.9 kDa
AP Mol Mass

17-23 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Research Areas

immunology
Reconstitution

Please refer to the printed manual for detailed information.

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