Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform ‘, ‘ binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor.
Recombinant Human VEGF121 protein(His tag)
£152.00 – £276.00 excluding VAT
| Size | 20µg, 50µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | A DNA sequence encoding theHuman VEGF121 protein (P15692-9) (Met1-Arg147) was expressed with a C-His. |
| Sequence | Met1-Arg147 |
| Fusion Tag | C-His |
| Accession | P15692-9 |
| Species | Human |
| Expressed Host | HEK293 Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 17.2 kDa |
| AP Mol Mass | 14 kDa;18 kDa |
| Formulation | Lyophilized from sterile PBS, pH 7.5, 5% trehalose, 5% mannitol, 0.01% tween-80. |
| Research Areas | |
| Reconstitution | Please refer to the printed manual for detailed information. |
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