Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
Recombinant Mouse 4-1BB/TNFRSF9 Protein (aa 24-187, Fc Tag)(Active)
Immobilized Human 4-1BBL-His(Cat: PKSH032023) at 0.05μg/ml(100 μl/well) can bind Mouse 4-1BB-Fc.
Recombinant Mouse 4-1BB ligand receptor is produced by our Mammalian expression system and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus.
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
> 95 % as determined by reducing SDS-PAGE.
< 1.0 EU per μg as determined by the LAL method.
|Stability and Storage||
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|AP Mol Mass||
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.