APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer’s disease.
Size | 100µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | A DNA sequence encoding the mouse Aplp1 (NP_031493.2) (Met1-Glu584) was expressed with a polyhistidine tag at the C-terminus. |
Sequence | Met1-Glu584 |
Fusion Tag | C-His |
Accession | NP_031493.2 |
Species | Mouse |
Expressed Host | HEK293 Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 62.4 kDa |
AP Mol Mass | |
Formulation | Lyophilized from sterile PBS, pH 7.4 |
Research Areas | |
Reconstitution | Please refer to the printed manual for detailed information. |
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