Fagus Antibody Services

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Recombinant Mouse B2M/β2-MG Protein (His Tag)

£79.20£239.20 excluding VAT

β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

Size

20µg, 100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the Mouse B2M/β2-MG (P01887-1) (Ile21-Met119) was expressed with a polyhistidine tag at the N-terminus.

Sequence

Ile21-Met119

Fusion Tag

N-His

Accession

P01887-1

Species

Mouse

Expressed Host

E.coli

Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

Please contact us for more information.

Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Mol Mass

11.64kDa

AP Mol Mass

13kDa

Formulation

Supplied as sterile PBS, 25% glycerol, PH7.4

Research Areas
Reconstitution

Not Applicable

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