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Recombinant Mouse Cathepsin D/CTSD Protein (His Tag)

From: £142.40

SKU FAS-041238-P Category Tag

CTSD localizes to the lysosome and consists of a light chain and a heavy chain. CTSD is expressed in epithelial cells as well as in macrophages.CTSD is a lysosomal aspartyl protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes. It has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix and xonnective tissue. In addition, CTSD has been used as a breast cancer tumor marker.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Mouse Cathepsin D is produced by our Mammalian expression system and the target gene encoding Ile21-Leu410 is expressed with a 6His tag at the C-terminus.

Sequence

Ile21-Leu410

Fusion Tag

C-6His

Accession

NP_034113.1

Species

Mouse

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

43.9 kDa

AP Mol Mass

56kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH5.5.

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.