Fagus Antibody Services

Linkedin Twitter
Linkedin Twitter

Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)

£93.60 – £237.60 excluding VAT

SKU FAS-041229-P Category Tag

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Size

10µg, 50µg
Active Protein
Activity
Protein Construction

Recombinant Mouse Death Receptor 6 is produced by our Mammalian expression system and the target gene encoding Gln42-His349 is expressed with a Fc, 6His tag at the C-terminus.
Sequence

Gln42-His349
Fusion Tag

C-6His
Accession

NP_055267.1
Species

Mouse
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

64.7 kDa
AP Mol Mass
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Research Areas

Cell biology
Reconstitution

Please refer to the printed manual for detailed information.

Related Product

Related products

All Products