Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Recombinant Mouse Granzyme B(G,H)/GZMB Protein (His Tag)
£178.40 – £474.40 excluding VAT
SKU
FAS-041035-P
Category Protein
Tag Granzyme B(G;H);CTLA-1;Cytotoxic cell protease 1;CCP1;Fragmentin-2;Gzmb;Ctla-1; Ctla1
Size | 10µg, 50µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Recombinant Mouse Granzyme B is produced by our Mammalian expression system and the target gene encoding Gly19-Ser247 is expressed with a 6His tag at the C-terminus. |
Sequence | Gly19-Ser247 |
Fusion Tag | C-6His |
Accession | P04187 |
Species | Mouse |
Expressed Host | Human Cells |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
Purity | > 85 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass | 26.5 kDa |
AP Mol Mass | 35kDa |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
Research Areas | |
Reconstitution | Not Applicable |
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