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Recombinant Mouse IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-6His)

£216.00 – £646.40 excluding VAT

SKU FAS-041429-P Category Tag

Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

Size

10µg, 50µg
Active Protein
Activity
Protein Construction

Recombinant Mouse Interleukin-6 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Leu20-Pro364 is expressed with a 6His tag at the C-terminus.
Sequence

Leu20-Pro364
Fusion Tag

C-6His
Accession

P22272
Species

Mouse
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

38.9 kDa
AP Mol Mass

50-65 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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