Kallikreins belongs to the family of trypsin-like serine proteases, many of which are associated with a variety of cancers. Kallikrein 1 (KLK1) is also known as tissue kallikrein and urinary kallikrein. KLK1 is synthesized as a 261 amino acid (aa) protein that contains a 18 aa signal peptide and a 241 aa proprotein. An important physiological function of KLK1 cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Kinins regulate vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.
Recombinant Mouse Kallikrein 1/KLK1 Protein (His Tag)
From: £142.40
Size | 10µg, 50µg |
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Active Protein | |
Activity | |
Protein Construction | Recombinant Mouse Kallikrein-1 is produced by our Mammalian expression system and the target gene encoding Pro19-Asp261 is expressed with a 6His tag at the C-terminus. |
Sequence | Pro19-Asp261 |
Fusion Tag | C-His |
Accession | P15947 |
Species | Mouse |
Expressed Host | Human Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 27.9 kDa |
AP Mol Mass | 34-38 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH7.5. |
Research Areas | |
Reconstitution | Please refer to the printed manual for detailed information. |