MARCO (macrophage receptor with collagenous structure) is an 80 kDa type II transmembrane glycoprotein that belongs to the class Ascavenger receptor family. Mouse MARCO consists of a 48 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 449 aa extracellulardomain (ECD) that includes a stalk region, a collagenlikeregion, and one SRCR domain. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. MARCO binds LPS, lipoteichoic acid, and otherdeterminants on Gram positive and Gram negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2.
Recombinant Mouse MARCO is produced by our Mammalian expression system and the target gene encoding Gln70-Ser518 is expressed with a 8His tag at the N-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
> 90 % as determined by reducing SDS-PAGE.
< 1.0 EU per μg as determined by the LAL method.
|Stability and Storage||
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|AP Mol Mass||
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Please refer to the printed manual for detailed information.