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Recombinant Mouse Nectin-4 (C-Fc)

From: £100.00

SKU FAS-041375-P Category Tag

Nectin-4(PVRL4)isatypeItransmembraneglycoproteinwhichbelongstothenectinfamilyofIgsuperfamilyproteins.ItcontainstwoIg-likeC2-typedomainsandoneIg-likeV-typedomain.PVRL4seemstobeinvolvedincelladhesionthroughtrans-homophilicand-heterophilicinteractions,thelatterincludingspecificallyinteractionswithnectin-1.Itdoesnotactasreceptorforalpha-herpesvirusentryintocells.Itispredominantlyexpressedinplacenta,theembryoandbreastcarcinoma.Butitisnotdetectedinnormalbreastepithelium.Thesolubleformisproducedbyproteolyticcleavageatthecellsurface(shedding),probablybyADAM17.Mutationsinthisgenearethecauseofectodermaldysplasia-syndactylysyndrometype 1, an autosomal recessive disorder.

Size

10µg, 50µg
Active Protein

Active protein
Activity

Immobilized Recombinant Mouse Nectin-4 (C-6His)(Cat#PKSM041376) at 10μg/ml (100 μl/well) can bind Recombinant Mouse Nectin-4 (C-Fc)(Cat#PKSM041375). The ED50 of PKSM041375 is 0.75 ug/ml.
Protein Construction

Recombinant Mouse Poliovirus Receptor-Related Protein  4 is produced by our Mammalian expression system and the target gene encoding Gly31-Ser349 is expressed with a Fc tag at the C-terminus.
Sequence

Gly31-Ser349
Fusion Tag

C-Fc
Accession

Q8R007
Species

Mouse
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

61.4kDa
AP Mol Mass

75-85kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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