Fagus Antibody Services

Recombinant Mouse SCARB2/LIMPII Protein (His Tag)

£93.60£237.60 excluding VAT

SKU FAS-041136-P Category

Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Mouse Lysosomal Integral Membrane Protein II is produced by our Mammalian expression system and the target gene encoding Arg27-Thr432 is expressed with a Fc tag at the C-terminus.

Sequence

Arg27-Thr432

Fusion Tag

N-6His

Accession

O35114

Species

Mouse

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

73.4 kDa

AP Mol Mass

90-120 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of 50mM Tris-Citrate, 0.3M NaCl, pH6.5.

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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