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Recombinant Mouse SCF/c-Kit Ligand Protein (His Tag)

£115.20 – £332.80 excluding VAT

SKU FAS-041311-P Category Tag

SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

Size

10µg, 50µg
Active Protein
Activity
Protein Construction

Recombinant Mouse SCF is produced by our Mammalian expression system and the target gene encoding Lys26-Ala189 is expressed with a 6His tag at the C-terminus.
Sequence

Lys26-Ala189
Fusion Tag

C-His
Accession

P20826
Species

Mouse
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

19.3 kDa
AP Mol Mass

19-35 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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