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Recombinant Mouse Semaphorin-4A/SEMA4A Protein (His Tag)

£142.40 – £418.40 excluding VAT

SKU FAS-041139-P Category Tag

Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12. SEMA4A is a cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. It plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A promotes phosphorylation of TIMD2, inhibits angiogenesis, and promotes axon growth cone collapse, Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Size

10µg, 50µg
Active Protein
Activity
Protein Construction

Recombinant Mouse Semaphorin 4A is produced by our Mammalian expression system and the target gene encoding Thr33-His682 is expressed with a 6His tag at the C-terminus.
Sequence

Thr33-His682
Fusion Tag

C-6His
Accession

Q62178
Species

Mouse
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

72.7 kDa
AP Mol Mass

70-90 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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