Fagus Antibody Services

Recombinant Rat c-MPL/CD110/TPOR Protein (His Tag)

£585.60 excluding VAT

SKU FAS-030214-P Category Tag

CD110, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for c-mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopeniawhich is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.

Size

100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the mature form of rat MPL (Met1-Ala500) was expressed with a polyhistide tag at the C-terminus.

Sequence

Met1-Ala500

Fusion Tag

C-His

Accession
Species

Rat

Expressed Host

Baculovirus-Insect Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

55.1 kDa

AP Mol Mass

55 kDa

Formulation

Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10%glycerol, pH 7.5

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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