Fagus Antibody Services

Recombinant Rat CCL4/MIP1B Protein(His Tag)

£684.00£745.60 excluding VAT

SKU FAS-030127-P Category Tag

CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.

Size

100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the rat Ccl4 (NP_446310.1) (Ala24-Asn92) was expressed with a polyhistidine tag at the C-terminus.

Sequence

Ala24-Asn92

Fusion Tag

C-His

Accession

NP_446310.1

Species

Rat

Expressed Host

Yeast

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

Please contact us for more information.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

9.2 kDa

AP Mol Mass
Formulation

Lyophilized from sterile 30 % CAN, 0.1 % TFA

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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