Fagus Antibody Services

Recombinant Rat IL6RA/CD126 Protein (ECD, His Tag)(Active)

£585.60£684.00 excluding VAT

SKU FAS-030142-P Category Tag

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called ‘trans-signalling’ mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Size

50µg

Active Protein

Active protein

Activity

Measured by its ability to bind human IL6 in functional ELISA.

Protein Construction

A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with a polyhistidine tag at the C-terminus.

Sequence

Met1-Pro364

Fusion Tag

C-His

Accession

NP_058716.2

Species

Rat

Expressed Host

HEK293 Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

39.5 kDa

AP Mol Mass
Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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