TSC22D1 (TSC22 domain family member 1) encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of TSC22D1 has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TSC22D1.
ELISA, IF, IHC, WB
Human 1, Mouse, Rat
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