HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
HLA-DPB1 Polyclonal Antibody
£256.00 – £530.00 excluding VAT
SKU
FAS-66192-A
Category Polyclonal Antibody
Tags class II, DP beta 1, DPB1, HLA-DP, HLA-DP1B, HLA-DPB, HLA-DPB1, major histocompatibility complex
Size | 120μL, 200μL |
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Swissprot | P04440 |
Applications | IHC |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Research Areas | Cancer, Immunology |
Concentration | 1 mg/mL |
Storage | Store at -20°C. Avoid freeze / thaw cycles. |
Immunogen | Recombinant fusion protein of human HLA-DPB1 (NP_002112.3). |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Purification Method | Affinity purification |
Dilution | IHC 1:50-1:200 |
Conjugation | Unconjugated |
Clonality | |
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