IL-27,a member of IL-12/IL-23 heterodimeric family of cytokines,has pleiotropic properties that can enhance or limit immune responses. IL-27 is a heterodimeric cytokine composed of two subunits: IL-27a and IL-27b. IL-27 acts on various cell types,including T cells,B cells,macrophages,dendritic cells,natural killer (NK) cells and non-hematopoietic cells. IL-27 plays a critical role in the early regulation of T helper type 1 initiation,and enhances proliferation of naive CD4+T cells and naive B cells. It,however,also exerts anti-inflammatory functions by inhibiting the development of Th17 cells and inducing IL-10 producing type 1 regulatory T cells. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases.
IL27 Polyclonal Antibody
£184.00 – £380.00 excluding VAT
| Size | 120μL, 200μL |
|---|---|
| Swissprot | Q8NEV9 |
| Applications | IHC |
| Reactivity | Human |
| Host | Rabbit |
| Isotype | IgG |
| Research Areas | Cancer, Immunology |
| Concentration | 2 mg/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Immunogen | Recombinant Human Interleukin-27 subunit alpha protien |
| Buffer | PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
| Purification Method | Affinity purification |
| Dilution | IHC 1:100-1:400 |
| Conjugation | Unconjugated |
| Clonality | Polyclonal |
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