Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
Human, Mouse, Rat
Cancer, Cell Biology, Metabolism, Signal Transduction
Store at -20°C. Avoid freeze / thaw cycles.
Recombinant fusion protein of human AK2 (NP_001616.1).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
WB 1:500-1:2000 IHC 1:50-1:200
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