Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5′ to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Cancer, Cardiovascular, Epigenetics and Nuclear Signaling
Store at -20°C. Avoid freeze / thaw cycles.
Recombinant fusion protein of human APEX1 (NP_542380.1).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
WB 1:500-1:2000 IF 1:50-1:100
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