Fagus Antibody Services

(KO Validated) BAX Polyclonal Antibody

£288.00£580.00 excluding VAT

SKU FAS-63606-A Category Tags ,

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Size

120μL, 200μL

Swissprot

Q07812

Applications

WB, IHC

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Research Areas

Cancer, Cell Biology, Metabolism

Concentration

1 mg/mL

Storage

Store at -20°C. Avoid freeze / thaw cycles.

Immunogen

A synthetic peptide of human BAX (NP_620116.1).

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method

Affinity purification

Dilution

WB 1:500-1:2000 IHC 1:100-1:200

Conjugation

Unconjugated

Clonality

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