Fagus Antibody Services

(KO Validated) CBX3 Polyclonal Antibody

£288.00£580.00 excluding VAT

SKU FAS-62382-A Category Tags , , ,

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5′ UTR, have been found for this gene.

Size

120μL, 200μL

Swissprot

Q13185

Applications

WB, IHC, IF

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Research Areas

Cancer, Epigenetics and Nuclear Signaling

Concentration

1 mg/mL

Storage

Store at -20°C. Avoid freeze / thaw cycles.

Immunogen

Recombinant fusion protein of human CBX3 (NP_009207.2).

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method

Affinity purification

Dilution

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Conjugation

Unconjugated

Clonality

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