This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Cancer, Epigenetics and Nuclear Signaling
Store at -20°C. Avoid freeze / thaw cycles.
Recombinant fusion protein of human DNMT1 (NP_001370.1).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
WB 1:500-1:2000 IF 1:50-1:200
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