The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3′ untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
WB, IHC, IF
Cancer, Epigenetics and Nuclear Signaling
Store at -20°C. Avoid freeze / thaw cycles.
A synthetic peptide of human HuR / ELAVL1 (NP_001410.2).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
WB 1:500-1:1000 IHC 1:50-1:200 IF 1:50-1:200
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