May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
CK-17 Monoclonal Antibody
£192.00 – £319.20 excluding VAT
| Size | 120μL, 200μL |
|---|---|
| Swissprot | Q04695 |
| Applications | IF, IHC-p, IP, WB |
| Reactivity | Human 1 |
| Host | Mouse |
| Isotype | IgG |
| Research Areas | Cancer, Signal Transduction |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Immunogen | Synthetic Peptide |
| Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Purification Method | Protein A purification |
| Dilution | WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300 |
| Conjugation | Unconjugated |
| Clonality | Monoclonal |
| Citation Link 1 | |
| Citation Link 2 | |
| Citation Link 3 | |
| Citation Link 4 | |
| Citation Link 5 |
