FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
FAS Monoclonal Antibody
£192.00 – £399.00 excluding VAT
| Size | 120μL, 200μL |
|---|---|
| Swissprot | P25445, P25446 |
| Applications | IHC |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Isotype | IgG |
| Research Areas | Cancer, Cell Biology, Immunology |
| Concentration | 420 ?g/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse FAS |
| Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Dilution | IHC 1:200-1:800 |
| Conjugation | Unconjugated |
| Clonality | Monoclonal |
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