Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.
Recombinant Mouse NCR1 Protein (His Tag)
£88.80 – £237.60 excluding VAT
| Size | 10µg, 50µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | Recombinant Mouse Natural cytotoxicity triggering receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a Fc tag at the C-terminus. |
| Sequence | Glu22-Asn255 |
| Fusion Tag | C-6His |
| Accession | Q8C567 |
| Species | Mouse |
| Expressed Host | Human Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 53.5 kDa |
| AP Mol Mass | 76kDa |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 . |
| Research Areas | |
| Reconstitution | Please refer to the printed manual for detailed information. |
