Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Catenin beta Monoclonal Antibody
£192.00 – £319.20 excluding VAT
| Size | 120μL, 200μL |
|---|---|
| Swissprot | P35222 |
| Applications | IF, IHC-p, WB |
| Reactivity | Human 1, Mouse, Rat |
| Host | Mouse |
| Isotype | IgG |
| Research Areas | Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Immunogen | Recombinant Protein |
| Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Purification Method | Protein A purification |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300 |
| Conjugation | Unconjugated |
| Clonality | Monoclonal |
| Citation Link 1 | |
| Citation Link 2 | |
| Citation Link 3 | |
| Citation Link 4 | |
| Citation Link 5 |
Related Product
Related products
-
-
-
-
-
-
Phosphorylated antibody
Phospho-Catenin beta (Ser37) Polyclonal Antibody
£192.00 – £319.20 excluding VAT -
-
-
-