Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
(KO Validated) NUDT1 Polyclonal Antibody
£288.00 – £580.00 excluding VAT
Size | 120μL, 200μL |
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Swissprot | P36639 |
Applications | WB, IHC |
Reactivity | Human |
Host | Rabbit |
Isotype | IgG |
Research Areas | Cancer, Epigenetics and Nuclear Signaling |
Concentration | 1 mg/mL |
Storage | Store at -20°C. Avoid freeze / thaw cycles. |
Immunogen | Recombinant fusion protein of human NUDT1 (NP_945192.1). |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Purification Method | Affinity purification |
Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
Conjugation | Unconjugated |
Clonality | |
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